Your Simple Guide to Ketamine Therapy Treatment Types

Know the Facts: Ketamine Therapy Topics That Matter

From IV infusions to lozenges, this guide walks through the different ways of how ketamine therapy is delivered, so you can ask the right questions and explore your options with confidence.

Exploring ketamine treatment for the first time can feel like a big step. With several formats available, it helps to understand how each one works and what the experience might involve.
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Each format is delivered differently and may feel different in the body, but all are used as part of a care plan guided by a qualified provider.

A patient prepares to use nasal ketamine prescribed by their doctor.

A patient is relaxed during their clinical ketamine therapy with headphones and a sleep-mask over their eyes and a blanket.

"I didn’t know what to expect with ketamine therapy, but having these guides made a huge difference."

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A doctor holds ketamine troche's to show a patient's options.

How Ketamine Is Often Prescribed

Ketamine can be administered in several different ways.

Each delivery method affects how the medicine enters the body, how long it takes to start working, and where the treatment is delivered. Some formats are always administered in a clinic setting. Others, like lozenges, may be prescribed for at-home use but still require medical supervision and follow-up.

‍Ketamine Treatment Options In Clinics Often Include:
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These typically include: an intravenous (IV) drip, a nasal spray (Spravato®), an intramuscular (IM) injection, a subcutaneous (SC) injection, and lozenges that dissolve under the tongue. Each method is approved for specific conditions.

Ketamine Treatments At Home Often Include:

These typically include oral troches or lozenges that dissolve under the tongue, as well as a nasal spray approved for specific conditions.

There is no single best option. What works best depends on your needs, your medical history, and the kind of support that helps you feel most at ease. Your ketamine provider will work with you to determine the best course of care for your medical needs.

Ketamine Therapy Types and What to Expect

What are the different ways to receive ketamine therapy?

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Each method is different, but all can be part of a supportive care plan.

1.

IV KETAMINE INFUSIONS: A Clinical, Monitored Approach
Delivered through a slow drip into the bloodstream, IV infusions take place in a clinic under direct supervision. This option is often used when adjustments are helpful or when larger doses are needed. Sessions include close monitoring and often involve multiple treatments over several weeks or months. Treatment plans are followed up through check-ins or maintenance visits.

2.

INTRAMUSCULAR INJECTIONS: A Lower Dose In-Clinic Option
Intramuscular (IM) ketamine is given as a single injection, often in the thigh or upper arm. This method may involve shorter appointments. Some people may notice effects within minutes. The dose is set beforehand, and treatment is still supervised in a clinical setting.

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INTRANASAL SPRAVATO: FDA-Approved and Structured
Spravato (esketamine) is approved by the FDA for certain forms of depression. The nasal spray is administered in a certified clinic under medical observation. It follows a scheduled protocol and may be covered by insurance in some cases. Your care team will help you understand eligibility and what to expect during each visit.

4.

ORAL LOZENGES (TROCHES): Flexible Dosage Options
Lozenges are placed under the tongue and slowly dissolve. They can be used as the primary treatment method and can also be used as part of a maintenance plan after in-clinic care. This method is slower to take effect and can vary in timing depending on the individual. If prescribed for at-home use, lozenges should be part of a medically supervised care plan with clear guidance.

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SUBCUTANEOUS INJECTIONS: A Small-Dose In-Clinic Option
‍Subcutaneous (SC) injections are given just under the skin, often in the belly or thigh. This option uses a shorter needle and a lower dose than IV or IM. It’s typically done in a clinic setting and may be used as part of a slower-paced treatment plan. Your provider will guide when and how this method is used.

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AT-HOME NASAL SPRAY: A Convenient Option With Guidance
Some providers prescribe ketamine nasal spray, that is different from Spravato, for at-home use. This option is often part of a personalized treatment plan and may be used to support symptoms like depression or anxiety. While it’s designed for self-administration, it should always be guided by a provider, with regular check-ins to ensure safe and effective use.

Building a Plan That Works for You

There is no one-size-fits-all approach to ketamine therapy.

Some people prefer the structure and monitoring of in-clinic treatments. Others may benefit from more flexible formats they can use at home with guidance.

The most important thing is feeling supported throughout your care.
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Many clinics now offer additional tools like guided audio, journaling prompts, or group support to help with reflection and integration.

These resources are not a replacement for therapy but can help you stay connected to your healing between sessions.

A patient sits in a ketamine clinic with headphones and an eyemask.

A patient ans a provider have a conversation about treatment options.

Start With Understanding, Then Take the Next Step

You don’t have to have it all figured out today.

‍The right type of ketamine therapy depends on many things: your current health, affordabilty, your goals, your comfort level, and what your provider recommends.

It’s okay if you’re still exploring. You do not need to make any decisions right away. Take your time, ask questions, and think about what feels safe and manageable for you.

Feeling informed and supported is just as important as the treatment itself, and it starts with conversations that meet you where you are.

FAQs

Common Questions From Ketamine Patients

What’s the difference between IV, IM, nasal spray, and oral ketamine?

The main difference is how the medicine enters your body. IV is given through a drip, IM is a single injection, nasal spray is inhaled through the nose, and oral ketamine (lozenges) dissolve under your tongue. Each method has a different pace, setting, and level of supervision.

How do I know which type of ketamine therapy is right for me?

There’s no one-size-fits-all answer. Your ketamine doctor will consider your symptoms, medical history, comfort level, and lifestyle when discussing options with you. It's okay to take your time and ask questions before choosing a treatment type.

Is ketamine therapy covered by insurance?

Some clinics accept insurance, but many operate privately. It’s a good idea to ask about pricing, payment plans, and what’s included before starting treatment.

Is one type more effective than the others?

Each type of ketamine therapy works differently, and effectiveness can vary from person to person. What’s most important is choosing a format that feels manageable and safe for you, in partnership with a ketamine provider who understands your needs.

Looking for a Ketamine Therapy Clinic in the U.S.?

Finding the right ketamine provider can feel overwhelming. We’re here to make it simpler. Use our directory to search trusted clinics across the U.S. and explore resources designed to help you feel informed and supported at every step.

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Resources Every Ketamine Patient Should Read

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A patient is relaxed during their ketamine therapy with headphones and a sleep-mask over their eyes.