5 Tips for Spravato: Maximizing Your Esketamine Treatment Experience

At The Ketamine Channel, we understand that considering Spravato® (esketamine) therapy can be both exciting and overwhelming. As the first FDA-approved ketamine-based treatment for depression, Spravato has provided new hope for individuals struggling with treatment-resistant depression (TRD). However, because it is administered differently from traditional antidepressants, patients often have questions about what to expect, how to prepare, and how to make the most of each session.

To help you feel confident and informed, we’ve gathered expert insights, practical tips, and real-world advice from those who have undergone Spravato therapy. This guide will walk you through five key strategies to ensure that you get the best possible experience and results from your treatment.

Understanding Spravato: How It Works and What to Expect

Spravato® is a nasal spray form of esketamine, a ketamine-derived medication that targets the brain’s glutamate system—unlike traditional antidepressants, which focus on serotonin and dopamine. It is prescribed for individuals with treatment-resistant depression (TRD) and, in some cases, major depressive disorder (MDD) with suicidal ideation.

Unlike at-home nasal ketamine or lozenges, Spravato must be administered in a certified medical facility under supervision. Each session lasts around two hours, during which patients are monitored for side effects such as dizziness, dissociation, or nausea. Many individuals begin to notice improvement within a few weeks, though a full treatment plan typically spans several months.

Now, let’s explore five expert-backed tips to help you get the most out of your Spravato journey.

1. Prepare for Each Session by Planning Ahead

Because Spravato is administered in a clinical setting, patients must follow certain pre-treatment guidelines to ensure a smooth experience.

What You Can Do to Prepare:

• Plan for a ride home: Spravato can cause drowsiness and dissociation, so you won’t be allowed to drive yourself home. Arrange for a friend, family member, or rideshare to pick you up.
• Follow your provider’s fasting recommendations: Some clinics suggest avoiding food for 2 hours before treatment and liquids for 30 minutes to reduce the risk of nausea.
• Dress comfortably: Sessions last about two hours, so wear comfortable clothing and bring items like a light blanket or eye mask if they help you relax.
• Have a calming playlist ready: Many patients find that listening to soothing music or guided meditations enhances their experience. Ask if your clinic provides personal headphones, if not, bring some.

2. Understand the Treatment Schedule and Stay Consistent

Spravato treatment follows a structured dosing schedule that is different from traditional antidepressants. Dosing may differ per patient, but typically patients may receive:

• Twice-weekly treatments for the first 4 weeks
• Once-weekly treatments for weeks 5-8
• Ongoing maintenance treatments (which may be spaced every 2-4 weeks, depending on response)

Why Staying Consistent Matters:

• Results build over time—while some patients notice improvements after a few sessions, others need the full induction phase to experience significant relief.
• Missing sessions can delay progress, as ketamine-based treatments rely on neuroplasticity—the brain’s ability to rewire and heal.
• Your provider may adjust your dosing based on your response, so consistent treatment ensures the best possible outcome.

If you ever need to miss or reschedule a session, communicate with your provider to adjust accordingly while maintaining your treatment plan.

3. Manage Side Effects Proactively

Like any medication, Spravato can cause mild to moderate side effects, but most are temporary and manageable.

Common Side Effects and How to Handle Them:

• Dissociation or feeling “spacey” → Relax in a comfortable setting and avoid stimulating environments for a few hours.
• Mild nausea → Taking anti-nausea medication before your session (if approved by your provider) can help.
• Dizziness or drowsiness → Avoid driving, operating heavy machinery, or making major decisions immediately after treatment.
• Temporary increase in blood pressure → Your clinic will monitor your vitals, but staying hydrated and avoiding excessive caffeine before treatment may help.

Many patients find that side effects lessen over time as their body adjusts to treatment. Communicate openly with your provider if side effects become bothersome—they may adjust your dosing or suggest additional support.

4. Use Integration Techniques to Strengthen Your Results

Spravato works by increasing neuroplasticity, meaning the brain becomes more adaptable and open to change. This makes it a great time to incorporate therapy, mindfulness, and positive behavioral changes to enhance treatment outcomes.

Ways to Make the Most of Your Neuroplasticity Window:

• Engage in therapy (especially CBT or ketamine-assisted psychotherapy) → Studies suggest that combining Spravato with psychotherapy leads to longer-lasting improvements in depression symptoms.
• Journal about your experience → Writing down thoughts, emotions, and insights after each session can help solidify mental shifts.
• Practice mindfulness or meditation → Techniques such as breathwork and grounding exercises can help integrate treatment benefits into daily life.
• Make small lifestyle changes → Since neuroplasticity is heightened, this may be a good time to introduce healthier habits like better sleep routines, nutrition, or exercise.

By incorporating these strategies, patients often experience deeper and more sustainable improvements over time.

5. Stay in Communication with Your Provider

Your provider is your partner in care, and maintaining open, ongoing communication ensures that you receive the best possible experience.

What to Discuss with Your Provider:

• Any changes in mood, energy, or symptom relief → Tracking progress helps refine your treatment plan.
• Concerns about side effects or dosing → Adjustments may be possible if needed.
• Long-term treatment planning → Some individuals transition to less frequent maintenance doses after initial improvements.

Spravato is a collaborative treatment, and your provider’s expertise is invaluable in ensuring you receive safe, effective, and personalized care. To find a provider that matches your needs, search The Ketamine Channel to research ketamine therapy providers who offer ketamine treatment types that match your health needs.

Exploring the Full Potential of Spravato

Spravato therapy is an advancement in the treatment of treatment-resistant depression, offering new hope to those who have struggled with traditional antidepressants. While the treatment process may feel unfamiliar at first, being well-prepared, informed, and engaged can help ensure the best possible results.

If you're considering Spravato or currently undergoing treatment, know that you are in the hands of highly trained professionals dedicated to your well-being. By following these expert-backed tips, you can maximize your treatment experience and take meaningful steps toward long-term improvement.